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3 plasmids (pGL1124, pGL1224 and pGL1217) have been produced to allow the substitute of 1 allele of CYC9, is distribute through the tsetse fly and causes trypanosomiasis in human beings and animals. The two the everyday living cycle and cell cycle with the parasite are sophisticated. Trypanosomes have eleven cdc2-related kinases (CRKs) and 10 cycli